# Septerna Inc. (SEPN) fundamentals

Data as of 2026-09-08. NASDAQ, United States. Sector: Healthcare / Biotechnology. Price $36.75, market value $1.7 billion.

## Valuation
- **P/E (trailing): n/a** (negative earnings). Septerna Inc. reported negative earnings over the last twelve months, so the P/E is not meaningful; use price-to-sales, EV/EBITDA and free-cash-flow yield instead.
- **Price / sales: 17.3×**. Each dollar of revenue is priced at 17.3×, a level that requires very high margins or very fast growth to justify.
- **Price / book: 4.4×**. The shares trade at 4.4× book value; book value is a meaningful part of the valuation.
- **Free-cash-flow yield: 6.1%** (5-yr avg -10.9%). Free cash flow equals 6.1% of the market value, above its five-year average of -10.9%, so the shares are cheaper on cash than they have usually been. Above 5% is generally attractive.

## Profitability
- **Operating margin: -44.0%**. Operating margin is negative: the business loses money before interest and tax.
- **Net margin: -106.4%**. The company reported a net loss over the last twelve months.
- **Return on equity: -12.8%**. Return on equity is negative because earnings are negative.
- **Return on assets: -4.1%**. Each dollar of assets produces -4.1% of profit.

## Growth
- **Revenue growth (1 yr): 4174.5%**. Revenue grew 4174.5% over the last year.
- **EPS growth (1 yr): 84.8%**. Earnings per share rose 84.8%, slower than revenue, so margins compressed.

## Financial health
- **Current ratio: 4.73** (quick 4.73). Current assets cover the next year's liabilities 4.73 times.
- **Altman Z-score: 6.05**. A Z-score of 6.05 places the company in the safe zone for bankruptcy risk.
- **Piotroski F-score: 4/9**. 4 of 9 checks pass: mixed.

## Dividends
- **Dividend: none**. Septerna Inc. does not currently pay a dividend.

## Price and momentum
- **Total return (1 yr): 160.3%** (YTD 31.8%, 3-mo 18.0%). The shares are up 160.3% over twelve months including dividends.
- **From 52-week high: -28.1%** (168.8% above the low). Trading 28% below its 52-week high.
- **200-day average: above**. The price sits above its 200-day moving average, the usual definition of an uptrend.
- **RSI (14-day): 41**. An RSI of 41 is neutral.
- **Beta (1 yr): 1.11** (volatility 68%). Beta of 1.11 against the S&P 500: the shares move roughly with the market.

Live score and charts: https://foliofundamentals.com/analyzer?s=SEPN · Page: https://foliofundamentals.com/stocks/sepn

Not investment advice.