# Upstream Bio Inc. (UPB) fundamentals

Data as of 2026-09-08. NASDAQ, United States. Sector: Healthcare / Biotechnology. Price $6.01, market value $329 million.

## Valuation
- **P/E (trailing): n/a** (negative earnings). Upstream Bio Inc. reported negative earnings over the last twelve months, so the P/E is not meaningful; use price-to-sales, EV/EBITDA and free-cash-flow yield instead.
- **Price / sales: 104.2×**. Each dollar of revenue is priced at 104.2×, a level that requires very high margins or very fast growth to justify.
- **Price / book: 1.1×**. The shares trade at 1.1× book value; book value is a meaningful part of the valuation.

## Profitability
- **Return on equity: -42.2%**. Return on equity is negative because earnings are negative.
- **Return on assets: -44.2%**. Each dollar of assets produces -44.2% of profit.

## Growth
- **Revenue growth (1 yr): 20.4%**. Revenue grew 20.4% over the last year.
- **EPS growth (1 yr): 52.3%**. Earnings per share rose 52.3%, faster than revenue, so margins expanded or the share count shrank.

## Financial health
- **Current ratio: 26.15** (quick 26.15). Current assets cover the next year's liabilities 26.15 times.
- **Altman Z-score: 15.11**. A Z-score of 15.11 places the company in the safe zone for bankruptcy risk.
- **Piotroski F-score: 2/9**. 2 of 9 checks pass: weak or deteriorating financials.

## Dividends
- **Dividend: none**. Upstream Bio Inc. does not currently pay a dividend.

## Analyst view
- **Analyst consensus: buy** (7 analysts). 7 analysts cover Upstream Bio Inc.; the consensus is buy, with an average price target of $31.14 (+418% from the current price). Analyst opinion is shown for context; it is not part of the Fundamental Score.

## Price and momentum
- **Total return (1 yr): -69.5%** (YTD -77.9%, 3-mo -14.8%). The shares are down 69.5% over twelve months including dividends.
- **From 52-week high: -82.2%** (4.2% above the low). Trading 82% below its 52-week high, deep in a drawdown.
- **200-day average: below**. The price sits below its 200-day moving average, the usual definition of a downtrend.
- **RSI (14-day): 37**. An RSI of 37 is neutral.
- **Beta (1 yr): 1.11** (volatility 88%). Beta of 1.11 against the S&P 500: the shares move roughly with the market.

Live score and charts: https://foliofundamentals.com/analyzer?s=UPB · Page: https://foliofundamentals.com/stocks/upb

Not investment advice.